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张西亚

发布时间：2023-10-13 13:29    浏览次数：
                                                                                                                                                 
姓名 张西亚 性别 男 出生年月 1987.04
民族 汉 籍贯 河南商丘 政治面貌 党员
部门 食品科学技术学院 职称 副教授/硕导 职务 无
办公地址 文化路校区1号楼222研究室 办公电话 037163558150 E-mail zhangxiya@henau.edu.cn
教授课程 《仪器分析》、《食品安全案例分析》、《食品免疫学》
研究方向 长期从事食品安全免疫分析快速检测方向的研究，擅长小分子化合物抗体制备及快速检测产品的开发。已经制备75种高性能的单克隆抗体，涵盖了常见的真菌毒素、兽药残留、农药残留相关项目。
教育经历 2013/09-2017/06，中国农业大学，动物医学基础兽医学专业，博士；
2008/09-2011/06，华中农业大学，动物医学基础兽医学专业，硕士；
2004/09年-2008/06，石河子大学，动物科技学院动物医学专业，学士。
学术社会兼职 药食质量安全数字化检测分会 理事；Coordination Chemistry Reviews, Journal of Agricultural and Food Chemistry, Food Chemistry等杂志审稿人。
科研项目 1. 国家基金面上项目，32472436，果蔬中蛋白、脂肪及金属离子产生侧流层析免疫分析基质效应的机制及消除研究，2025/1-2028/12，在研，主持。
2. 国家基金面上项目，32172298，半抗原中苯环间隔臂连接位点制备抗原对抗体灵敏度影响机制研究，2022/1-2025/12，结项，主持。
3. 国家青年基金项目，31802249，“turn-on”型荧光能量共振转移侧流层析猝灭效率机制研究及体系的构建，2019/1-2021/12，结项，主持。
4. 河南省高校科技创新人才，25HASTIT044，抗体定向标记减弱果蔬中干扰蛋白产生免疫层析基质效应的研究，2025/1-2027/12，在研，主持。
5. 河南省优秀青年，252300421161，低共熔溶剂减弱高脂肪样本产生的侧流层析基质干扰机制及应用研究，2025/1-2027/12，在研，主持。
6. 河南科技攻关项目，222102310162，均一识别性泰乐菌素/替米考星抗体的分子识别机制及应用研究，2022/1-2023/12，结项，主持。
7. 河南省高等学校重点科研项目，20A550009，样品富集净化与可视化检测一体化新型免疫分析方法研究，2019/12-2021/12，结项，主持。
8. 河南省高等学校大学生创新训练计划项目，201910466023，苯环邻位、间位和对位作为间隔臂连接位点对小分子化合物特异性抗体产生的影响机制研究，2019/5-2021/4，项目指导老师，结项。
9．河南农业大学青年人才项目，30500645，荧光能量共振转移侧流层析体系的构建，2018/6-2023/5，结项，主持。
10. 河南农业大学拔尖人才项目，30501305，2022/10-2027/9，在研，主持。
论文论著 近5年以第一作者或通讯作者发表SCI论文：
  1. Tong Bu, Changwei Luo, Mengzhuo Fan, Yu Wang, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Xiya Zhang*. Advances in bioluminescence resonance energy transfer systems: Donor-acceptor design, transfer efficiency improvement, and applications. Coordination Chemistry Reviews, 2025, 543, 216937.
  2. Qianqian Cui#,Huijuan Yang#, Zizhe Li, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Tong Bu,* Xiya Zhang*.Antibody Affinity Modulation Mechanisms via Benzene Ring Spacer Arm Conjugation Sites (Ortho, Meta, Para) in Coating Hapten Design. Analytical Chemistry, 2026, 98(10), 7663-7675.
  3. Yexuan Mao , Jinkui Wang , Changwei Luo , Meng Dang , Dan Hai , Xianqing Huang , Lianjun Song , Xiya Zhang * , Tong Bu*. Orientational probes-powered sensitive and accurate immunochromatographic assays with reduced antibody consumption and diminished matrix interference. Food Chemistry, 2026, 508:148338.
  4. Changwei Luo#, Mengzhuo Fan#, Mengtian Chen, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Tong Bu,* and Xiya Zhang*. Engineered CeO2@Ru Nanospheres via Size-Metal-Loading Synergy to Enhance Chemiluminescence Efficiency for Sensitive Immunochromatographic Assay. Small, 2025, 21(34), 2503909.
  5. Mingyue Ding# , Leina Dou#, Tong Bu, Zizhe Li, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Zhanhui Wang, Xiya Zhang*, Nanometal Surface Energy Transfer-based Lateral Flow Immunoassay for T2 Toxin Detection. Biosensors and Bioelectronics, 2025, 267(1), 116779.
  6. Xiya Zhang#, Qianqian Cui#, Mingyue Ding, Yexuan Mao, Xianqing Huang, Lianjun Song, Tong Bu*, Fortified Donor−Acceptor Spectral Overlap Facilitated Fluorescence Quenching Efficiency for Developing Sensitive Nanometal Surface Energy Transfer-Based Immunochromatographic Test Strips, Analytical Chemistry, 2025, 97: 5209-5216.
  7. Jinkui Wang# , Tong Bu#, Qianqian Cui, Zizhe Li, Qing Xu, Zhixian Jiang, Yexuan Mao, Xianqing Huang, Lianjun Song, Dapeng Peng, Xiya Zhang*. A broad-spectrum antibody-based lateral flow immunoassay for detection of carbofuran and 3-hydroxy-carbofuran. Food Chemistry, 2025, 465:142062.
  8. Zizhe Li#, Qianqian Cui#, Qingyue Li, Changwei Luo, Mengtian Chen, Beibei Feng, Huan Li, Tong Bu, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Dapeng Peng, Xiya Zhang*. Preparation of ultra-sensitive anti-carbendazim antibodies based on new haptens and their application in lateral flow immunoassay. Sensors and Actuators B: Chemical, 2024, 135751.
  9. Lianjun Song#, Youyi Wang#, Qingyue Li, Jinkui Wang, Tian Gao, Zhaohuan An, Qinfang Liu, Yexuan Mao, Tong Bu, Xianqing Huang, Yan Ma, Zhanhui Wang, Xiya Zhang*. Production of monoclonal antibody against tylosin and tilmicosin with homogeneous cross‑reactivity and its application in lateral fow immunoassay. Microchimica Acta, 2024, 191(42).
  10. Yawei Sun, Xiangjie Deng, Changwei Luo, Wentao Ma, Wanjing Liu, Jinkui Wang, Qingyue Li, Tong Bu*,Xiya Zhang*. Time‑resolved fuorescence microspheres‑antibody‑penicillin‑binding protein assisted construction of immunochromatographic assay for sensitive detection of 22 β‑lactams in milk. Microchimica Acta, 2024, 191(50).
  11. Xiya Zhang#, Yuchen Bai#, Qianqian Tang, Minggang Liu, Li Nan, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Zhanhui Wang*, Development of epitopephore-based rational hapten design strategy: A combination of theoretical evidence and experimental validation. Journal of Hazardous Material, 2023(445),130615.
  12. Zizhe Li#, Jinkui Wang#, Youyi Wang, Qingyue Li, Xiaoyang Chen, Yu Wang, Haining Tian, Yexuan Mao, Lianjun Song, Xianqing Huang, Zhanhui Wang, Xiya Zhang*, Development of a lateral flow immunoassay based on a highly specific monoclonal antibody to detect 4- methylaminoantipyrine. Journal of Agricultural and Food Chemistry, 2023. 71:10841-10849
  13. Xiya Zhang#, Zizhe Li#, Yexuan Mao, Meng Dang, Xianqing Huang, Zhanhui Wang, Huijuan Yang, Yuchen Bai*, Huahai Zhang*Production of high-affinity monoclonal antibody and development of immunoassay for 3-methyl-quinoxaline-2-carboxylic acid detection in swine muscle and liver. Food Chemistry, 2023 (407), 135175.
  14. Yexuan Mao#, Yichao Fan#, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao*, Xiya Zhang*, A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. Electrochimica Acta, 461 (2023) , 142669.
  15. Qiuyan Zhao,‡  Mingyue Ding,‡  Dangshuai Pei, Xiuhua Qi, Yexuan Mao, Xianqing Huang, Lianjun Song, Jingnan Zuo, Huijuan Yang and  Xiya Zhang*Development of a monoclonal antibody-based lateral flow immunoassay for the detection of benzoic acid in liquid food. Analytical Methods, 2023,15, 6229-6238
  16. Meng Dang#, Zizhe Li#, Yexuan Mao, Xianqing Huang, Lianjun Song, Wenfeng Li, Ruxiang Ma, Yang Liu, Liye Wang, Xuezhi Yu, Huijuan Yang*, Xiya Zhang*, A highly sensitive lateral fow immunoassay based on a group‑specifc monoclonal antibody and amorphous carbon nanoparticles for detection of sulfonamides in milk. Microchimica Acta, 190 (2023):186.
  17. Yexuan Mao#, Meng Dang, Jianwei Zhang, Xianqing Huang, Mingwu Qiao, Lianjun Song, Qiuyan Zhao, Mingyue Ding, Youyi Wang, Zizhe Li, Ke Song, Qingge Shi, Xiya Zhang*, Peptide amphiphile inspired self-assembled, ordered gold nanocomposites for improved sensitivity of electrochemical immunosensor: Applications in determining the total aflatoxin amount in food stuffs. Talanta, 2022, 247:123532.
  18. Xiya Zhang#, Mingyue Ding#, Yexuan Mao, Xianqing Huang, Xinhua Xie, Lianjun Song, Mingwu Qiao, Jianwei Zhang, Tianlin Wang, Haihua Zhu, Zizhe Li, Youyi Wang, Meng Dang*, A comparative study of “turn-off” mode and “turn-on” mode lateral flow immunoassay for T-2 toxin detection. Sensors and Actuators B: Chemical, 2022, 359:131545.
  19. Liye Wang#, Jiangxiu Niu, Pengyuan Wei, Yilei Feng, Mingyue Ding, Chaojun He, Yongjie Ma, Yaolei Zhu, Jia Li, Lingli Huang*, Xiya Zhang*, Rapid determination of 2,4-diaminopyrimidine residues through sample pretreatment using immunomagnetic bead purification along with HPLC–UV. Food Chemistry, 2021(376), 131835.
  20. Xiya Zhang#, Mingyue Ding, Chensi Zhang, Yexuan Mao, Youyi Wang, Peipei Li, Haiyang Jiang, Zhanhui Wang, and Xuezhi Yu*, Development of a New Monoclonal Antibody against Brevetoxins in Oyster Samples Based on the Indirect Competitive Enzyme-Linked Immunosorbent Assay. Foods, 2021, 10, 2398.
  21. Zhang Xiya#, Xijie Zhang, Lianjun Song, Xianqing Huang, Yu Li, Mingwu Qiao, Wanjing Liu, Tongtong Zhang, Yuchen Qi, Wuzhou Wang, Xuezhi Yu, Leina Dou, Huijuan Yang, Liye Wang, Yexuan Mao*, Zhanhui Wang. An ultrasensitive, homogeneous fluorescence quenching immunoassay integrating separation and detection of aflatoxin M1 based on magnetic graphene composites, Microchimica Acta, 2021, 188(59).
  22. Xiya Zhang#, Fenfen Zhao, Tiejun Mi, Liye Wang, Qian Li, Jiayin Li, Wentao Ma, Wanjing Liu, Jingnan Zuo, Xinyu Chu, Bing Chen, Wenxin Han, Yexuan Mao*. Development of a highly sensitive lateral flow immunoassay based on receptor-antibody-amorphous carbon nanoparticles to detect 22 β-lactams in milk. Sensors and Actuators B: Chemical, 2020, 321:128458.
成果奖励 无
学术交流经历 经常参加食品安全、兽医药理学与毒理学、抗体大会、真菌毒素等相关研究的国内及国际会议。
荣誉称号 河南省青年五四奖、河南省教育厅学术技术带头人、优秀班主任

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